pentobarbital will reduce the extent or outcome of etravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will decrease the level or effect of bexarotene by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will increase toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers might improve the metabolism of ifosfamide to its Lively alkylating metabolites.
pentobarbital will raise the stage or outcome of ivosidenib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of ivosidenib with strong CYP3A4 inducers reduced ivosidenib plasma concentrations.
If this drug is used throughout pregnancy, or In the event the individual gets to be Expecting whilst having this drug, the client needs to be apprised of the potential hazard into the fetus
pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can decrease panobinostat ranges by ~70% and cause treatment method failure.
pentobarbital will lower the level or effect of pimozide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.
pentobarbital boosts toxicity of methoxyflurane by expanding metabolism. Contraindicated. Elevated metabolism of methoxyflurane to nephrotoxic compounds.
pentobarbital decreases amounts of ponatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Stay away from Except if the coadministration outweighs the attainable chance of ponatinib underexposure; keep track of for indications of lowered efficacy.
Contraindicated (1)pentobarbital will reduce the level or influence of naloxegol by get more info influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with robust CYP3A4 inducers is not really advised
pentobarbital will lessen the extent or effect of tamoxifen by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.
With therapeutic doses of TCAs, barbiturates raise metabolism and reduce blood concentrations of TCAs.
pentobarbital will minimize the level or result of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.